In the case of chronic fatigue syndrome, fibromyalgia, multiple sclerosis, ALS, autism, Alzheimer’s, lupus, and Lyme disease, inflammatory proteins called cytokines cross into the brain. They do this through weakened areas of the blood-brain barrier (BBB). In the brain, they cause “mental confusion”, sleep disturbances, and increased pain, depression, and anxiety. Certain cytokines can deplete tryptophan from the brain, which is necessary in the production of serotonin.
Low serotonin levels can lead to poor sleep, depression, increased stress, increased appetite, increased perception of pain due to increased Substance P, and IBS (irritable bowel syndrome). Decreased serotonin and increased substance P can result in low growth hormone (HGH) production, which is characteristic of fibromyalgia.
This tryptophan deficiency is especially damaging for those suffering from depression, anxiety, chronic Lyme syndrome, chronic fatigue syndrome, and fibromyalgia, who already struggle with low serotonin levels.
It is important to strengthen the blood-brain barrier (BBB) against cytokine invasion. Cytokines will only cross the BBB in a weakened area. Low levels of vitamin B, a deficiency of certain essential fatty acids, and a viral infection, such as a cold or the flu, can weaken the blood-brain barrier. A study published in June 2002, in the scientific journal Differentiation, reported new evidence that radiation from mobile phones can also weaken the BBB against harmful substances. (Wireless phones pose the same risk, but to a lesser degree.)
Diet and dietary supplements can strengthen the brain’s protective barrier (BBB) against cytokine invasion. Because vitamin C can strengthen capillaries and the blood-brain barrier is made up of capillaries, it is reasonable to believe that vitamin C could provide the BBB with additional protection. Additionally, animal studies show that flavonoids, such as those found in blueberries, cranberries, and grape seeds, can protect the blood-brain barrier. These flavonoids can be purchased in supplement form. They are also anti-inflammatory, so they protect the brain by reducing cytokine levels and strengthening the BBB.